The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or untrained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.